The Centers for Medicare & Medicaid Services (CMS) has released its October 2026 quarterly update to the Healthcare Common Procedure Coding System, commonly known as HCPCS Level II.
The revised code set becomes effective on October 1, 2026. Healthcare practices, medical billing teams, suppliers, and coding professionals should review the changes before the effective date to reduce the risk of rejected claims, incorrect code selection, and payment delays.
The October update includes:
- 88 new HCPCS Level II codes
- 14 discontinued codes
- 11 long-description revisions
- Five codes with payment-related changes
- One code with an administrative-field change
Many of the additions involve wound-care products, infusion equipment, orthoses, ocular devices, drugs, and other supplies not represented within the CPT® code set.
What Are HCPCS Level II Codes?
HCPCS Level II codes are primarily used to report medical products, supplies, drugs, durable medical equipment, prosthetics, orthotics, and certain services that are not included in CPT codes.
While CPT codes generally describe physician and outpatient procedures, HCPCS Level II codes help payers identify other billable healthcare items. These codes commonly begin with a letter followed by four numbers.
Examples include:
- A codes for certain medical and surgical supplies
- E codes for durable medical equipment
- J codes for drugs administered other than orally
- L codes for orthotic and prosthetic procedures and devices
- Q codes for temporary codes assigned to certain services and supplies
Because CMS updates HCPCS Level II codes throughout the year, practices should not rely solely on the code set loaded at the beginning of 2026.
Notable New Codes Effective October 1, 2026
The quarterly update introduces several codes for wound-care materials, infusion equipment, ocular devices, and orthotic products. The following are selected examples rather than the complete list.
New wound-care product codes
Several of the new codes describe wound dressings, collagen matrices, and allograft wound coverings.
Examples include:
- A2046 – DermiSphere hDRT, reported per square centimeter as an add-on code
- A2047 – LacertaMatrix, reported per square centimeter as an add-on code
- A2048 – PuraPly MZ, reported per milligram
- A2049 – Theracor, reported per square centimeter as an add-on code
- A2050 – Fibrillar collagen wound dressing, reported per milligram
- Q4207 – Carbon Life, reported per square centimeter as an add-on code
- Q4223 – DermaBind SL Optic, reported per square centimeter as an add-on code
- Q4243 – AmchoMatrix, reported per square centimeter as an add-on code
These additions may affect wound-care clinics, podiatry practices, surgical providers, outpatient departments, and organizations that furnish advanced wound-care products.
Practices should verify the applicable unit of measurement before submitting claims. Confusing square centimeters, milligrams, or individual units can result in inaccurate quantities and payment problems.
Infusion equipment and supply codes
CMS has also added codes related to certain device-drug combination infusion systems.
These include:
- A4228 – Supplies used to maintain a non-insulin device-drug combination infusion catheter, reported per week
- E0788 – A wearable ambulatory infusion pump used for a specific device-drug combination
A new code does not automatically establish coverage for every patient or clinical situation. Providers should still confirm payer coverage, medical-necessity requirements, documentation rules, and any applicable prior authorization requirements.
Ocular pressure equipment
Two new codes relate to external ocular negative-pressure equipment:
- A6614 – Monthly supplies and accessories used with an external ocular negative-pressure pump
- E2403 – An electric external ocular negative-pressure pump
Ophthalmology practices and equipment suppliers that provide these products should confirm which party is responsible for billing the device and its accessories.
Orthotic and replacement-device codes
The update also introduces or revises codes affecting orthotic products and replacement components.
Notable examples include:
- L1330 – A prefabricated thoracic orthosis designed for sternal or sternocostal compression
- L1972 – A prefabricated, off-the-shelf ankle-foot orthosis with an ankle joint
- L8697 – A replacement external accessory used with an implantable phrenic nerve stimulation device
The creation of L1972 is particularly important because it distinguishes an off-the-shelf ankle-foot orthosis from an item requiring customization by an appropriately skilled individual.
Selecting between off-the-shelf and custom-fitted orthosis codes should be based on the product furnished, the work performed, and the supporting documentation—not simply on which code has a higher payment rate.
Revised HCPCS Code Descriptions
CMS revised 11 long code descriptions in the October update.
Among these changes are revisions to L8030, L8031, and L8035, which describe certain breast prostheses. The updated language clarifies that these codes can apply to “any type” of qualifying breast prosthesis within the applicable code description.
A descriptor revision may appear less significant than the introduction of a new code, but it can still affect:
- Product-to-code mapping
- Medical record documentation
- Charge descriptions
- Claim edits
- Payer coverage policies
- Staff coding instructions
Billing teams should review the complete revised descriptors rather than relying on abbreviated code descriptions displayed within an EHR or practice management system.
Deleted Codes Require Immediate Attention
The October update discontinues 14 HCPCS Level II codes.
One example is L8696, which is discontinued effective October 1 because its application overlaps with the newly established L8697.
Claims using a deleted code for services provided on or after its termination date may be rejected or denied. However, the appropriate code is generally determined by the date of service, so historical claims should not be changed automatically.
Before replacing a discontinued code, verify:
- The claim’s date of service
- The termination date of the former code
- The effective date of the replacement code
- Whether the new code accurately describes the product or service
- Whether payer-specific billing instructions apply
There may not always be a direct one-to-one replacement for every deleted code.
Drug Codes Also Changed
The J-code section includes new codes, discontinued codes, and revised descriptions.
J codes are commonly used for drugs administered by injection, infusion, or another method rather than through self-administration. Mistakes involving these codes can be especially costly because claim accuracy may depend on the drug strength, billing unit, package size, discarded amount, and payer policy.
Practices billing J codes should review:
- The exact drug and formulation
- The HCPCS billing unit
- The administered quantity
- Any discarded-drug reporting requirements
- Applicable modifiers
- National Drug Code information
- Payer-specific coverage and authorization requirements
The drug name alone is not enough to confirm that a particular J code is correct.
Payment and Administrative Changes
CMS identified payment-related changes for A2040 through A2043 and A2045.
The update also includes an administrative-field change for E0150, which describes a combination wheeled walker with a seat and transport chair.
A payment update does not necessarily mean that every provider will receive the same reimbursement. Actual payment can depend on the payer, fee schedule, contract, location, setting, coverage policy, and claim circumstances.
Practices should confirm applicable reimbursement information through current payer resources rather than treating a published national amount as a guaranteed payment.
What Healthcare Practices Should Do Before October 1
The operational effect of a coding update extends beyond the coding department. Charge-entry staff, clinicians, billers, suppliers, and software vendors may all be involved.
Healthcare organizations should consider completing the following steps:
Review the official CMS files
Download the October 2026 Alpha-Numeric HCPCS file directly from CMS and identify changes relevant to the services, drugs, equipment, and supplies your organization provides.
Update billing systems
Confirm that your EHR, charge master, billing platform, claim-scrubbing software, and coding references will contain the new code set by October 1.
Do not assume the update has been installed simply because the software vendor normally performs automatic updates.
Map discontinued codes carefully
Identify any deleted codes currently used by the practice. Determine whether CMS established a replacement and whether that replacement applies to the same product or service.
Review templates and order sets
Update frequently used charge templates, encounter forms, preference lists, product records, and documentation prompts. Old codes saved in templates can continue generating errors even after the primary code database has been updated.
Verify payer requirements
CMS establishes the HCPCS Level II code set, but individual payers may apply different coverage, authorization, documentation, and reimbursement policies.
Check Medicare Administrative Contractor guidance and applicable commercial payer policies before billing a new code.
Monitor claims after implementation
Closely review rejections, denials, and payment variances for claims containing newly added or revised codes. Early monitoring can help identify system configuration problems before they affect a larger group of claims.
Why Quarterly Coding Updates Matter to Revenue Cycle Performance
An overlooked code change can affect several parts of the revenue cycle.
A discontinued code may trigger a front-end rejection. An incorrect unit may cause overbilling or underbilling. An outdated product description may create a documentation mismatch. A new code submitted without checking payer requirements may result in a medical-necessity or authorization denial.
Preparing before the effective date helps practices:
- Reduce preventable claim rejections
- Improve coding consistency
- Protect billing accuracy
- Identify payer requirements earlier
- Reduce avoidable rework
- Support more timely reimbursement
Coding updates should therefore be treated as a coordinated revenue cycle task rather than a simple software change.
Prepare Your Billing Workflow for the October Update
The October 2026 HCPCS Level II update introduces meaningful changes for organizations that bill drugs, wound-care products, infusion equipment, orthoses, prostheses, and durable medical equipment.
Every new code will not apply to every practice. The priority is to identify the changes connected to the products and services your organization actually provides and then update the related systems, documentation, and payer-verification processes.
Greenhive Billing Solutions helps healthcare practices manage medical coding, claim submission, denial follow-up, and other revenue cycle responsibilities. If your practice needs help reviewing the billing impact of coding changes, contact our team to discuss your current workflow.
Official Source
The complete October 2026 Alpha-Numeric HCPCS file is available on the CMS HCPCS Quarterly Update page. CMS lists the October file as updated on August 18, 2026, with the code changes effective October 1, 2026.
Disclaimer: This article is provided for general informational purposes only and does not constitute medical, legal, compliance, reimbursement, or professional coding advice. Code selection, coverage, documentation, and payment requirements may vary by payer and clinical circumstances. Review the official CMS files and applicable payer guidance before submitting claims. CPT® is a registered trademark of the American Medical Association. Greenhive Billing Solutions is not affiliated with or endorsed by CMS or the American Medical Association.










